David Gilmour's newly released single from his new solo album starts with him playing uke, and it remains a prominent background element throughout much of the song. Check it out.
I read something about how this album was produced. He used some fairly young producer, and said he loved working with him because he WASN'T familiar with his body of work and challenged him to do things differently. "Does there need to be a guitar solo here?" Nobody else would ever ask David Gilmour that question!