Radius fretboard setup?

Is a radiused fretboard more challenging to set up properly than one without a radius?
I would think that you’ve got to match the radius of your nut slots to the radius of the fretboard, else 2 strings will be higher than the others over the frets.
 
I don't think it's any harder to setup based on my guitars (which all have various radius fretboard except for one guitar).
 
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